CASE REPORT article
Front. Pediatr.
Sec. Neonatology
Genetically confirmed severe hemophilia A in a preterm infant: A case report
- LM
Lanjun Mu 1
- NZ
ning zou 2
- LZ
Li Zhang 2
1. Second Affiliated Hospital of Dalian Medical University, Dalian, China
2. The Second Hospital of Dalian Medical University, Dalian, China
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Abstract
Severe hemophilia A is exceptionally rare among preterm infants. Qwing to immature coagulation system and nonspecific bleeding manifestations, the condition is readily misdiagnosed as other neonatal hemorrhagic disorders, such as vitamin K deficiency, neonatal sepsis and thrombocytopenia. Delayed diagnosis will greatly increase the risk of severe complications, particularly intracranial hemorrhage. Herein, we report a case of genetically confirmed severe hemophilia A in a 34-week preterm infant without family history of hemophilia. Treatment comprised sequential adminnistration of coagulation factor VIII repalcement and emicizumab. We futher analyze the clinical characteristics, diagnostic difficulties and standardized management principles of hemophilia A in preterm infants, so as to improve clinicians' awareness, reduce misdiagnosis and missed diagnosis, and optimize the long-term prognosis of affected infants.
Summary
Keywords
Coagulation factor VIII, Emicizumab, neonatal hemorrhage, preterm infant, Severe hemophilia A
Received
24 March 2026
Accepted
03 August 2026
Copyright
© 2026 Mu, zou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lanjun Mu; ning zou
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