https://www.frontiersin.org/journals/pediatrics RSS Feed for Frontiers in Pediatrics | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-08-10T17:31:43.583+00:00 60 https://www.frontiersin.org/articles/10.3389/fped.2026.1818320 https://www.frontiersin.org/articles/10.3389/fped.2026.1818320 2026-08-10T00:00:00Z Review Shuzhe XiaoQi ZhengLingling WangZhiqiu WangGuangliang BiJie Yang https://www.frontiersin.org/articles/10.3389/fped.2026.1889280 https://www.frontiersin.org/articles/10.3389/fped.2026.1889280 2026-08-10T00:00:00Z Original Research Sevgi Büyükbeşe Sarsu https://www.frontiersin.org/articles/10.3389/fped.2026.1918653 https://www.frontiersin.org/articles/10.3389/fped.2026.1918653 2026-08-10T00:00:00Z Case Report Ilaria BuconiLorna SpagnolLeonardo CrescentiniGiovanni RolloLetizia CorbiMassimiliano Silveri https://www.frontiersin.org/articles/10.3389/fped.2026.1837801 https://www.frontiersin.org/articles/10.3389/fped.2026.1837801 2026-08-10T00:00:00Z Original Research Tsepo L. TsekoaLusisizwe KweziPriyen PillaySibongile MtimkaMaabo MoraloKabamba AlexandreJoseph NkololaDan H. BarouchRachel Chikwamba https://www.frontiersin.org/articles/10.3389/fped.2026.1888442 https://www.frontiersin.org/articles/10.3389/fped.2026.1888442 2026-08-10T00:00:00Z Case Report Mariam MarzoukiMalek MezniYosra Ben AhmedWiem HammoudaRim Ben AzizaImen Ben IsmailSaid JlidiAya KhemirImen Abess https://www.frontiersin.org/articles/10.3389/fped.2026.1902579 https://www.frontiersin.org/articles/10.3389/fped.2026.1902579 2026-08-07T00:00:00Z Original Research Yehui LanLiyu TangMiao JinBin DuJianfei YanQuanzhou WuChenying LuYanhua HuangZhihui Chen https://www.frontiersin.org/articles/10.3389/fped.2026.1730779 https://www.frontiersin.org/articles/10.3389/fped.2026.1730779 2026-08-07T00:00:00Z Systematic Review Lijuan ZhouHui MengLiming Cao https://www.frontiersin.org/articles/10.3389/fped.2026.1896889 https://www.frontiersin.org/articles/10.3389/fped.2026.1896889 2026-08-07T00:00:00Z Original Research Mingsheng ZhengWenwei LingJingyi ZhangRong JuTiantian XiaoYiyong FuBiao LiYi ZhengJun WangXiaofeng ZhouGaoyang QinLingping ZhongLing ZhuYouning HuXiaolong ZhangZhengwei YeHuaying LiYang LiuNana WuShuqiang GaoXuhong HuYan JiangXiaohong Luo 32 weeks with early aPH receiving iNO treatment and without structural cardiopulmonary anomalies in a single-center retrospective study, the implementation of the NICUltra workflow is associated with significantly improved clinical efficacy and may be useful for optimizing clinical strategies with no observed differences in short-term outcomes.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1852266 https://www.frontiersin.org/articles/10.3389/fped.2026.1852266 2026-08-07T00:00:00Z Original Research Qianliang WangQingling Liu https://www.frontiersin.org/articles/10.3389/fped.2026.1903927 https://www.frontiersin.org/articles/10.3389/fped.2026.1903927 2026-08-07T00:00:00Z Original Research Jing LiWei Kai Wang https://www.frontiersin.org/articles/10.3389/fped.2026.1859038 https://www.frontiersin.org/articles/10.3389/fped.2026.1859038 2026-08-06T00:00:00Z Original Research Abdiasis Aden OmerHamda Jama YousufMohamed Hussein EgehAhmed Abdirahman FarahAli Ahmed HusseinFatima Nouh IsmailBashir Mohamed Mohamoud https://www.frontiersin.org/articles/10.3389/fped.2026.1874110 https://www.frontiersin.org/articles/10.3389/fped.2026.1874110 2026-08-06T00:00:00Z Case Report Guodun ZhengDengke LuoTaozhen HeMiao YuanGang YangShiyi DaiChang Xu https://www.frontiersin.org/articles/10.3389/fped.2026.1869213 https://www.frontiersin.org/articles/10.3389/fped.2026.1869213 2026-08-06T00:00:00Z Clinical Trial Jin GaoHanmei XiongChuanfeng LiWeihong YuJie YangPanrong NieLingyun BaoHong YangYuan Shi  0.05). However, post-intubation arterial pH was lower in the NDT-InSurE group than in the LISA group (7.27 [7.25–7.35] vs. 7.38 [7.32–7.42], P = 0.004). Moreover, the incidence of major complications, including bronchopulmonary dysplasia, intraventricular hemorrhage, retinopathy of prematurity, and necrotizing enterocolitis, did not differ significantly between groups.ConclusionsNDT-InSurE may serve as a practical alternative to LISA, particularly in settings where LISA expertise or resources are limited. Further large-scale, multicenter studies with long-term follow-up are warranted to confirm these findings and further evaluate the efficacy and safety of this technique.Clinical Trial RegistrationThis study was registered at the China Clinical Trial Registry (https://www.chictr.org.cn/), Registration Number: ChiCTR2300076354.The registration date is October 7th, 2023.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1880763 https://www.frontiersin.org/articles/10.3389/fped.2026.1880763 2026-08-06T00:00:00Z Original Research Bailey B. ZeilerTimothy M. BahrKhanh V. LaiJoel L. AddamsElizabeth F. StoneErica A. SwensonRobin K. OhlsRobert D. Christensen https://www.frontiersin.org/articles/10.3389/fped.2026.1880157 https://www.frontiersin.org/articles/10.3389/fped.2026.1880157 2026-08-05T00:00:00Z Original Research Wenmiao XuJingya SunJian JiJiansheng ZengZheng LiQuan WangChaonan FanSuyun Qian https://www.frontiersin.org/articles/10.3389/fped.2026.1827163 https://www.frontiersin.org/articles/10.3389/fped.2026.1827163 2026-08-05T00:00:00Z Original Research Ruibao YangShangShang RenJie LinMan SunGuangliang Jiang https://www.frontiersin.org/articles/10.3389/fped.2026.1900675 https://www.frontiersin.org/articles/10.3389/fped.2026.1900675 2026-08-05T00:00:00Z Brief Research Report J. Geoffrey ChaseHelen D. Shannon  1.0 are interpreted as evidence of exogenous or factitious insulin dosing. However, recently published data from pre-term neonates with no insulin dosing or family history of diabetes show far higher ratios. How can these “inverted” ratios happen without factitious insulin poisoning?HypothesisInsulin binding antibodies explain the incidence and magnitude of “inverted” I/C ratios in this NICU cohort?MethodA secondary analysis integrating three independent evidence streams with mechanistic modelling study. Three “siloed” areas of neonatal research were integrated: (1) paired insulin and C-Peptide measurements from two NICU cohorts (227 and 75 matched samples) from infants not receiving insulin and with no immediate family history of diabetes or insulin use illustrates the incidence of unexpected I/C > 0.1–0.2; (2) Analysis of direct measurements of affinity, displacement and binding-site capacity across 5 independent studies constrain neonatal binding affinity and concentration; and (3) Analysis of binding kinetics of reversible insulin-binding reactions. Results of #2–3 are combined with a clinically validated neonatal metabolic model to assess whether they could account for observed I/C > 1.0 from #1.ResultsFor #1, over 80% of NICU infants had I/C > 0.1 and 40% had I/C > 1.0 consistent with circulating bound insulin measured by some immunoassays. #2, Independent affinity measurements, displacement studies, direct concentration measurements, and reconstruction from I/C data converged on a dominant high-affinity, low-nanomolar binding regime. #3, Model-based analysis of antibody binding reactions reproduced the observed I/C ratios and high apparent insulin concentrations without requiring extreme assumptions.ConclusionHigh I/C ratios are not uncommon in NICU neonates and can be explained by high-affinity insulin-binding activity rather than insulin administration. Multiple independent quantitative analyses converge on a common high-affinity, low-nanomolar binding regime which reproduces observed I/C ratios. Critical illness, such as sepsis, significantly increases the levels and likelihood of unexpected high I/C ratios.]]> https://www.frontiersin.org/articles/10.3389/fped.2026.1902619 https://www.frontiersin.org/articles/10.3389/fped.2026.1902619 2026-08-05T00:00:00Z Review Lei YangQiaoling FanLingyan FanJiayu Qiu https://www.frontiersin.org/articles/10.3389/fped.2026.1847049 https://www.frontiersin.org/articles/10.3389/fped.2026.1847049 2026-08-05T00:00:00Z Original Research Chun LiangXifeng ZhangLian Zhao https://www.frontiersin.org/articles/10.3389/fped.2026.1862189 https://www.frontiersin.org/articles/10.3389/fped.2026.1862189 2026-08-05T00:00:00Z Systematic Review Di WangRongkun ZhuXiaoxuan MaJing ZhaoCong ShangXiwei Hao