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        <title>Frontiers in Pediatrics | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/pediatrics</link>
        <description>RSS Feed for Frontiers in Pediatrics | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-08-19T16:19:03.632+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1926830</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1926830</link>
        <title><![CDATA[Case Report: Vincristine extravasation managed with amniotic membrane graft in a pediatric patient with Wilms tumor]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Fatma Betul Ozen</author><author>Ayse Oz</author><author>Sultan Aydin</author>
        <description><![CDATA[Vincristine is a commonly used chemotherapeutic agent in pediatric oncology and, because of its vesicant properties, may cause severe tissue injury in cases of extravasation. We present a pediatric case in which tissue damage developing after vincristine extravasation during treatment for Wilms tumor was managed with an amniotic membrane graft following clinical progression despite standard conservative measures. A 2 year eight month old boy developed vincristine extravasation from a peripheral intravenous line on the dorsolateral aspect of the left foot during week 24 of carboplatin–vincristine chemotherapy for Stage II Wilms tumor. The progression of tissue injury despite initial conservative management suggested that amniotic membrane grafting may represent a useful alternative therapeutic option, especially in extravasation injuries involving functionally critical regions that do not respond adequately to conventional approaches.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1756844</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1756844</link>
        <title><![CDATA[Gestational diabetes and its influence on early neurodevelopment in infants: a retrospective analysis]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Dan Liu</author><author>Xiaoxia Chen</author><author>Yili Zhang</author><author>Biao Chen</author>
        <description><![CDATA[Background & objectiveGestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes, but its impact on early cognitive function and neurodevelopment remains uncertain. This study evaluates cognitive and developmental outcomes in infants born to mothers with GDM compared to non-diseased mothers.MethodsA retrospective cohort study was conducted in infants born to mothers with or without GDM. Cognitive development was assessed using the Bayley Scales of Infant Development for Chinese Revision (BSID-CR), and developmental quotient (DQ) scores were extracted for analysis. Developmental concerns were identified from infant assessment records. Logistic and linear regression analyses were applied to determine associations between GDM and early developmental outcomes, adjusting for maternal and neonatal variables.ResultsA total of 292 infants (145 born to mothers with GDM vs. 147 controls) were eligible for study. Maternal and neonatal characteristics were comparable between the GDM and control groups. No significant differences were observed between the groups in developmental concern occurrence (32.0% vs. 33.1%, p = 0.837) or corrected BSID-CR DQ score [median 94 (IQR, 83–103) vs. 96 (IQR, 85–102), p = 0.813]. The revised logistic model showed no independent association between GDM and developmental concern occurrence (OR = 1.090, 95% CI 0.602–1.972, p = 0.776), and the revised linear model showed no independent association between GDM and corrected BSID-CR DQ score (B = −0.069, 95% CI −3.807 to 3.670, p = 0.971).ConclusionInfants born to mothers with GDM demonstrated comparable cognitive and developmental outcomes to controls. Moreover, GDM may not independently impact cognitive development in infancy when managed appropriately.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1872306</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1872306</link>
        <title><![CDATA[Case Report: STAT3 hyper-IgE syndrome in children: two cases report with uncommon complications of tuberculosis and lymphoma]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Xiaobei Cao</author><author>Bo Wang</author><author>Yongsheng Xu</author>
        <description><![CDATA[BackgroundHyper-IgE syndrome (HIES) is a rare primary immunodeficiency disorder distinguished by a triad of eczema, recurrent skin and pulmonary infections, and elevated serum IgE levels. The loss-of-function mutations in signal transducer and activator of transcription 3 (STAT3) result in STAT3-HIES, which is considered the prototype form of HIES. Patients with STAT3-HIES are susceptible to Staphylococcus aureus and Candida albicans, while Mycobacterium tuberculosis infection is rare, usually accompanied by multiple non-immunologic features including skeletal and connective tissue abnormalities, and the increasing risk of lymphoma. Owing to the diverse clinical manifestations of this disease and the lack of specific symptoms in its early stage, delayed diagnosis often occurs.Case presentationThis report describes two cases of children with STAT3-HIES. One case was a 3-year-old child who presented with intestinal intussusception as the initial symptom and was considered to have probable intestinal tuberculosis and accompanied by miliary pulmonary tuberculosis, and tuberculosis was cured after one year of anti-infection treatment, HIES combined with intestinal tuberculosis presenting with intussusception as the clinical manifestation has never been reported. Second case was a 16-year-old child who was diagnosed with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma because of swollen lymph nodes in the neck at the age of 10, he underwent allogeneic hematopoietic stem cell transplantation when he was 16 years old, unfortunately he died of lung infection after three months.ConclusionThe cases described in this article enhance our understanding of the manifestations, treatment and prognosis of this syndrome, highlighting the hazards of active tuberculosis and lymphoma in patients with HIES, as well as the importance of timely diagnosis, individualized treatment and follow-up.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1908774</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1908774</link>
        <title><![CDATA[Prediction of chronicity in pediatric immune thrombocytopenia based on developed and internally validated machine learning models]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Xiaoqin Zhang</author><author>Benshan Zhang</author><author>Wanli Li</author><author>Yang Liu</author><author>Huimin Xu</author><author>Zhijun Huang</author><author>Wenyong Kuang</author>
        <description><![CDATA[BackgroundPrimary immune thrombocytopenia (ITP) typically remits spontaneously, 20%–30% of children progress to chronic ITP. Early prediction of chronicity in ITP may facilitate in timely intervention and improve prognosis.MethodsIn our current study, we collected clinical features such as platelet-specific antibodies and used machine learning (ML) to predict chronic progression of ITP. ML models were applied to data from our hospital. Model performance was evaluated using accuracy, precision, sensitivity, specificity, F1 score, and area under the receiver operating characteristic (ROC) curve to assess the binary classification models performance.ResultsA total of 156 patients were enrolled for ITP classification prediction model construction, including 68 chronic patients and 88 non-chronic patients. All models performed well, with AUC values ranging from 0.833 to 0.864. The ET model was selected for predictive model construction due to its highest AUROC score and interpretability. Then, the ET model identified occult disease course, age, and platelet-specific antibodies as significant predictors. The absence of an occult disease course decreased the probability of chronic ITP, while older age increased it. It's worth noting when platelet-specific antibodies are negative, patients are less likely to develop chronic ITP.ConclusionsIn conclusion, the ET model achieved high prediction accuracy for ITP chronicity by using clinical parameters, especially platelet-specific antibodies. Despite the limited sample size, this study suggests occult disease course, age, and platelet-specific antibodies are early predictors of chronic ITP in children, meriting confirmed in future larger cohort multicenter study.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1830735</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1830735</link>
        <title><![CDATA[Documented perioperative adverse events in paediatric anaesthesia in Mongolia: a first national baseline report]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Zolzaya Chinzorig</author><author>H. Reza Kahlaee</author><author>Kherlen Ponkhoon</author><author>Sergelen Sosor</author><author>Khulan Munkhtogtokh</author><author>Oyun Bayarsaikhan</author><author>Urantuya Khorolsaikhan</author><author>Khuanysh Ayatkhan</author><author>Bat-Undral Enkhbaatar</author><author>Ariunaa Purevsuren</author><author>Ariunzul Narmandakh</author><author>Ganzul Baasandorj</author><author>Justin Skowno</author>
        <description><![CDATA[BackgroundPaediatric anaesthesia safety depends on reliable data regarding perioperative adverse events. However, many low- and middle-income countries lack integrated reporting systems, making it difficult to estimate risk, identify modifiable factors, or monitor safety improvement. Mongolia has developed paediatric anaesthesia services through national training and international collaboration; however, no national system currently exists for systematic reporting of paediatric anaesthesia-related adverse events. This study aimed to provide the first national baseline description of documented perioperative adverse events in paediatric anaesthesia in Mongolia.MethodsWe conducted a multicentre retrospective chart review at the main tertiary paediatric hospital and five provincial hospitals providing paediatric surgical services in Mongolia. All paediatric anaesthetic procedures performed between 1 January 2018 and 31 December 2022 were eligible. Anaesthesia charts, recovery room records, intensive care records, and other relevant perioperative documents were manually reviewed. Documented adverse events were classified as cardiovascular, respiratory, neurological, or other perioperative events. Results were summarized descriptively at the record and event levels.ResultsAcross 60,546 paediatric anaesthetic procedures, 640 records contained documentation of at least one perioperative adverse event. After exclusion of three records with insufficient documentation, 637 records were included in the final analysis. These records included a total of 1,159 documented perioperative adverse events, corresponding to 19.1 documented events per 1,000 procedures. Cardiovascular events were the most frequently documented category (n = 476, 41.1%; 7.9 per 1,000 procedures), followed by respiratory events (n = 283, 24.4%; 4.7 per 1,000), other perioperative events (n = 264, 22.8%; 4.4 per 1,000), and neurological events (n = 136, 11.7%; 2.2 per 1,000). The most common event subtypes were tachycardia, laryngospasm, fever, hypotension, and bradycardia. Eleven serious adverse events were documented, comprising 10 cardiac arrests and one severe neurological injury. Cardiac arrest occurred at a rate of 0.17 per 1,000 procedures. No anaesthesia-related mortality was documented in the available anaesthesia records.ConclusionsThis study provides the first national baseline report on documented perioperative adverse events in paediatric anaesthesia in Mongolia. Cardiovascular and respiratory events were the most frequently documented categories, while serious adverse events were uncommon. Because this study relied on retrospective review of routine clinical records, the findings should be interpreted as documented event rates rather than definitive estimates of true incidence. These baseline data support the development of a prospective national reporting system, standardized event definitions, targeted training, and system-level safety improvements in Mongolian paediatric anaesthesia.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1932063</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1932063</link>
        <title><![CDATA[Predictive value of ultrasound findings for high-grade vesicoureteral reflux in children: a retrospective cross-sectional study in Saudi Arabia]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Abdulaziz S. Aljibali</author>
        <description><![CDATA[BackgroundVoiding cystourethrography (VCUG) remains the gold standard for diagnosing vesicoureteral reflux (VUR) but is invasive, involves ionizing radiation, and may cause considerable discomfort in children. Ultrasound offers a non-invasive alternative, although its ability to predict severe reflux remains uncertain. This study evaluated the predictive value of ultrasound findings for the detection of high-grade VUR and identified sonographic predictors associated with severe reflux in children.MethodsA retrospective cross-sectional study was conducted involving pediatric patients aged 0–14 years who underwent both renal and bladder ultrasound and VCUG between January 2018 and December 2024 in tertiary and secondary healthcare facilities in the Central Region of Saudi Arabia. Ultrasound variables including hydronephrosis severity, ureteral dilatation, cortical thinning, renal scarring, and bladder abnormalities were compared with VCUG findings. Chi-square analysis, multivariate logistic regression, receiver operating characteristic (ROC) analysis, and diagnostic performance measures were performed.ResultsA total of 406 children were included, with high-grade VUR identified in 50 patients (12.3%) on VCUG. Severe right and left hydronephrosis, ureteral dilatation, right cortical thinning, right renal scarring, and bladder distention were significantly associated with high-grade VUR (p < 0.05). Multivariate analysis identified left hydronephrosis (OR = 4.54), right hydronephrosis (OR = 4.18), bladder distention (OR = 4.18), and right renal scarring (OR = 3.76) as independent predictors. The combined ultrasound model demonstrated good discriminative ability (AUC = 0.824), sensitivity of 78.0%, specificity of 76.4%, positive predictive value of 31.7%, negative predictive value of 96.1%, and overall accuracy of 76.6%.ConclusionMultiparametric ultrasound is an effective screening tool for excluding high-grade VUR and may reduce unnecessary VCUG examinations but should not be seen as a replacement for VCUG.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1855210</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1855210</link>
        <title><![CDATA[Admission red cell distribution width–to–albumin ratio and risk of neonatal pneumonia or culture-proven sepsis in preterm infants: a retrospective cohort study]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Jiali Huang</author><author>Songbai Wang</author><author>Yuling Lin</author><author>Yongjian Zhao</author><author>Yingxiang Wang</author><author>Qinglin Rong</author><author>Xin Ye</author><author>Qiyin Cai</author>
        <description><![CDATA[BackgroundRed cell distribution width–to–albumin ratio (RAR), a biomarker reflecting inflammation and nutritional status, may be associated with adverse neonatal outcomes. Given that neonatal infection remains a major complication in preterm infants, this study aimed to evaluate the association between admission RAR and the risk of subsequent neonatal infection, and to explore potential non-linear patterns.MethodsThis retrospective cohort included 697 preterm infants (24⁰⁄₇–36⁶⁄₇ weeks) admitted to a tertiary NICU (2019–2024). RAR was calculated from RDW and albumin measured within 2 h of admission. The primary outcome was a subsequent composite neonatal infection during the NICU stay, defined as neonatal pneumonia and/or culture-proven sepsis. Multivariable logistic regression analyzed RAR continuously and by quartiles; restricted cubic splines and two-piecewise regression assessed non-linearity.ResultsInfants in higher RAR quartiles had lower gestational age and a higher incidence of subsequent composite neonatal infection. When analyzed as a continuous variable, RAR was not significantly associated with overall neonatal infection. However, in quartile analyses, higher RAR levels were independently associated with an increased risk of subsequent neonatal pneumonia, which accounted for the majority of infection events. No significant association was observed for culture-proven sepsis. A significant non-linear relationship between RAR and pneumonia risk was identified, with an apparent inflection point at 5.65 identified in exploratory restricted cubic spline analyses. Sensitivity analyses yielded consistent results.ConclusionAdmission RAR was non-linearly associated with the risk of subsequent neonatal pneumonia in preterm infants, with an apparent inflection point at 5.65 identified in exploratory analyses. Although RAR may serve as a complementary marker for risk stratification, its performance was comparable to albumin alone without evidence of superiority over established inflammatory markers. Further prospective studies are needed to confirm these results.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1807654</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1807654</link>
        <title><![CDATA[Neonatal tetanus in undocumented migrant families in Saudi Arabia: outcomes and critical care resource utilization in a 10-year tertiary PICU cohort]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Samah Al-Harbi</author><author>Abeer A. Alnajjar</author><author>Fidaa Al Maghrabi</author><author>Fatin A. Basnawi</author><author>Khouloud A. Al-Sofyani</author><author>Mohammed S. Uddin</author>
        <description><![CDATA[BackgroundNeonatal tetanus (NT) is an entirely preventable disease; however, it persists among underserved populations even within high-resource health systems. Contemporary data detailing outcomes in referral pediatric intensive care units (PICUs)—specifically regarding the intersection of low mortality and substantial resource utilization—remain limited.MethodsWe conducted a retrospective cohort study of 74 neonates with clinically confirmed NT admitted to a tertiary academic PICU in Saudi Arabia between 2014 and 2023. The cases met World Health Organization clinical criteria. We evaluated admission severity (Ablett grade), presenting clinical features and baseline laboratory indices as prognostic factors. Notably, postadmission therapies were excluded to preserve baseline prognostic interpretation and minimize confounding by indication. In-hospital mortality was analyzed using Firth bias-reduced logistic regression. Furthermore, resource-utilization outcomes—including invasive mechanical ventilation (IMV) duration, PICU length of stay (LOS), and hospital LOS—were modeled using accelerated failure time (AFT) regression. Internal validation for parsimonious mortality models utilized bootstrap optimism correction.ResultsIn-hospital mortality was 4.1% (3/74), occurring exclusively among infants graded Ablett III at admission. Conversely, resource utilization was substantial: median (IQR) IMV duration was 25.0 (16.0–30.0) days, PICU LOS was 32.0 (20.0–37.0) days, and hospital LOS was 40.0 (27.3–57.5) days. In parsimonious admission-only Firth models, higher birth weight showed an inverse association with lower mortality [adjusted odds ratios (aOR) 0.35 per SD, 95% confidence interval (CI) 0.09–0.85], while admission C-reactive protein showed a risk-increasing trend (aOR 1.81 per SD, 95% CI 0.87–3.92); given the fact that there were only three deaths, these estimates should be interpreted as directional signals rather than definitive independent predictors. In AFT models, septic shock on admission was associated with a shorter observed IMV duration (time ratio 0.05, 95% CI 0.002–0.947), most consistent with a mortality-related truncation of observed duration rather than accelerated clinical recovery. At 3–6 months, neurodevelopmental follow-up was available for 71 survivors, of whom 10 screened positive for developmental concerns (10/71; 14.1%).ConclusionIn this tertiary PICU cohort of neonatal tetanus in Saudi Arabia, mortality was low but critical-care utilization and early morbidity were substantial. Admission severity and inflammatory burden showed higher-risk signals, whereas birth weight showed a protective association; however, the small number of deaths limits precise inference. These findings quantify the PICU burden of a preventable disease and reinforce prevention priorities, including maternal vaccination, antenatal care, and safe delivery practices.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1895305</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1895305</link>
        <title><![CDATA[Influence of boundary layer conditions and surface properties on bacterial interaction with indoor built surfaces]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Dahae Seong</author><author>Shamia Hoque</author>
        <description><![CDATA[Indoor surface contamination is a significant concern in high-activity spaces such as childcare facilities, where microbial particles can be easily transmitted through direct surface touch or resuspension into indoor air. This study investigated Corynebacterium sp. attachment and detachment behaviors on four representative indoor surface materials (carpet, wood, metal and glass) and characterized near-surface airflow fields using batch attachment experiment, centrifugal detachment experiment, and particle image velocimetry (PIV). Surface characteristics: roughness, contact angle, and porosity were measured. The attachment fraction increased with exposure time for all tested surfaces, with metal (∼0.59), followed by wood (∼0.48) and glass (∼0.36). Carpet generated two microenvironments: an outer-fiber with higher-velocity region and an inter-fiber with lower-velocity shelter region. Glass showed the most uniform near-surface flows while wood generated the most spatially heterogeneous velocity fields due to its topography and pore structure. Overall, these results indicate that microbial attachment and detachment on indoor surface materials are governed by complex interplay of surface physicochemical properties, contact time, and geometry-dependent conditions, with no single factor acting alone. Smooth, non-porous surfaces could reduce initial adhesion and provide more predictable resuspension behavior in high-touch and high-activity indoor spaces.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1897604</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1897604</link>
        <title><![CDATA[Parental employment status and preschoolers' emotional and behavioral problems in Western China: a cross-sectional study]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Guiting Ren</author><author>Hongli Sun</author><author>Jingyu Bu</author>
        <description><![CDATA[ObjectivesGuided by the Family Economic Stress Model, this study investigated the associations between parental employment status and emotional and behavioral problems among preschoolers in Western China.MethodsThis cross-sectional study included 21,968 children aged 3–6 years recruited from 189 kindergartens. Parental employment status was categorized into four family-level patterns and further analyzed separately for paternal and maternal employment. Children's outcomes were assessed using the Strengths and Difficulties Questionnaire.ResultsFather-only employment was associated with higher internalizing problems (aOR = 1.11) but lower externalizing problems (aOR = 0.90); dual non-employment was associated with increased internalizing problems (aOR = 1.31). Paternal unemployment was linked to externalizing problems (aOR = 1.25), while maternal non-employment was associated with internalizing problems (aOR = 1.11–1.27). No significant effect modification was observed after FDR correction.ConclusionsParental employment status is associated with preschoolers' emotional and behavioral problems in a gender-differentiated manner. Paternal unemployment is primarily linked to externalizing problems, whereas maternal non-employment is more strongly associated with internalizing problems.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1917687</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1917687</link>
        <title><![CDATA[Commentary: Sport activities for children and adolescents: the position of the European Academy of Paediatrics and the European Confederation of Primary Care Paediatricians 2023—part 1: pre-participation physical evaluation in young athletes]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>General Commentary</category>
        <author>Abdullah Akkuş</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1833402</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1833402</link>
        <title><![CDATA[Preliminary transcriptome profiling of induced pluripotent stem cell-derived hematopoietic stem and progenitor cells in Kawasaki disease]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Lianni Mei</author><author>Lei Gao</author><author>Ruizhi Zhang</author><author>Qingzhu Qiu</author><author>Qiuping Lin</author><author>Libing Shen</author><author>Wenyuan Wang</author><author>Lijian Xie</author>
        <description><![CDATA[BackgroundThe etiology of Kawasaki disease (KD) remains unclear. Hematopoietic stem and progenitor cells (HSPCs) serve as the precursor cells for a multitude of immune cells. Investigating their initial transcriptional status may help uncover the aberrant immune mechanisms underlying KD.MethodsInduced pluripotent stem cells (iPSCs) were reprogrammed from peripheral blood mononuclear cells (PBMCs) isolated from patients with KD and febrile individuals, followed by directed differentiation into HSPCs. We performed bulk RNA-sequencing to compare transcriptomic profiles of iPSC-derived HSPCs between the two groups, with further comparison against integrated HSPC data from public KD single-cell datasets.ResultsWe recruited three patients with KD prior to Intravenous immunoglobulin (IVIG) therapy and three febrile control patients, and successfully established an iPSC-derived HSPCs disease model. Transcriptomic profiling revealed elevated immune and inflammatory response signatures in iPSC-derived HSPCs from patients with KD compared with those from febrile individuals. In addition, in vitro-generated KD iPSC-HSPCs exhibited partial transcriptional features similar to in vivo HSPCs isolated from PBMCs of patients with KD. Gene Set Enrichment Analysis (GSEA) further revealed that gene sets associated with B-cell developmental processes were transcriptionally downregulated in iPSC-derived HSPCs from patients with KD relative to febrile controls.ConclusionsiPSC-derived HSPCs from patients with KD display altered immune-inflammatory transcriptional profiles and suppressed B-cell developmental signatures at the transcriptomic level. These preliminary findings suggest that early hematopoietic immune dysregulation may contribute to KD pathogenesis. We propose that these iPSC-derived HSPCs could be a good cellular model for studying the etiology of KD in vitro. These findings are preliminary, constrained by the small sample size and limited to transcriptomic analysis only. Further studies with larger cohorts and functional experiments are needed to verify these results.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1932384</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1932384</link>
        <title><![CDATA[Congenital bronchopleural fistula in a newborn: a rare cause of persistent neonatal air leak – a case report]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Tomasz Janowicz</author><author>Michał Szostawicki</author>
        <description><![CDATA[BackgroundCongenital bronchopleural fistula is an exceptionally rare cause of persistent neonatal air leakage. Most bronchopleural fistulas in newborns are related to mechanical ventilation, infection, or iatrogenic injury. The clinical presentation can suggest pneumothorax commonly seen in premature infants, diagnosis is often delayed, and an ongoing uncontrolled air leak may significantly compromise effective ventilation.Case presentationA female neonate was delivered at 29 weeks of gestation with a birth weight of 1,360 g and Apgar scores of 6, 7, and 9. Immediately after birth, she developed progressive respiratory failure. Bilateral pneumothoraces were diagnosed, including a left tension pneumothorax. Despite two pleural drains and active suction, a continuous air leak persisted at approximately 800 mL/min, corresponding to the infant’s entire minute ventilation. Chest computed tomography demonstrated a communication between the left bronchial tree and the pleural cavity, consistent with a bronchopleural fistula. Dedicated CT angiography was not performed because of deterioration and the need to avoid delaying definitive treatment. Selective bronchial intubation, temporary bronchial occlusion with a Fogarty catheter, and minimally invasive options were considered. Owing to respiratory instability despite drainage, surgical treatment was selected. Thoracoscopy identified the lesion, but secure closure could not be achieved thoracoscopically; the procedure was converted to thoracotomy, and the fistula was excised with a segment of adjacent lung tissue. Postoperative bronchoscopy revealed tracheobronchial stenosis and left main bronchial malacia, which were managed conservatively. Genetic testing identified PAI-1/SERPINE1 and MTHFR variants, but these did not establish a recognised syndrome or causal association with the fistula. The postoperative respiratory course was favourable. At 18 months of age, the child had no recurrent pneumothorax, chronic respiratory symptoms, or late surgical complications.ConclusionPersistent high volume air leakage despite adequate pleural drainage should lead to suspect a major bronchial lesion and investigate congenital pulmonary and airway malformations. Conservative and bronchoscopic strategies may be effective in selected stable patients, whereas early surgery may provide definitive control in rapidly deteriorating neonates with a localised structural lesion. This case highlights the diagnostic value of CT, the need for individualised treatment selection, and the possibility of sustained long-term recovery after surgical repair.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1902593</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1902593</link>
        <title><![CDATA[Kawasaki disease following a pediatric scald burn: a case report and literature review]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Hanqin Ye</author><author>Kun Yang</author><author>Binjie Luo</author><author>Geng Ji</author><author>Xiaopeng Zheng</author>
        <description><![CDATA[BackgroundKawasaki disease (KD) is a systemic medium-vessel vasculitis of early childhood that, rarely, has been reported during the course of a pediatric burn. Because persistent fever, rash, and mucocutaneous changes overlap with the systemic inflammatory response to a burn wound, KD can go unrecognized, delaying the administration of intravenous immunoglobulin (IVIG), which reduces the risk of coronary sequelae.Case descriptionA previously healthy 1-year-old boy sustained a 6% total body surface area deep partial-thickness scald to the left lower limb. The wound healed with conservative dressing care and was almost completely re-epithelialized (>99%) by postburn day 10. On that same day, he developed an abrupt, persistent fever that peaked at 39.5°C–40°C and did not respond to empirical antibiotics. Over the next 48 h, he developed bilateral non-purulent bulbar conjunctival injection, erythematous cracked lips with a strawberry tongue, a polymorphous trunk rash, palmoplantar erythema with hand induration, and non-suppurative cervical lymphadenopathy (largest node 20 × 15 mm). Investigations showed neutrophilic leukocytosis (WBC 16.22 × 10⁹/L), a C-Reactive Protein (CRP) level of 42.65 mg/L, mild hyperbilirubinemia and transaminitis, and elevated levels of IL-6, soluble IL-2 receptor, and TNF-α. The platelet count was 456 × 10⁹/L at admission, 384 × 10⁹/L during the acute phase, and increased to 657 × 10⁹/L during convalescence. Infectious and rheumatological differentials were excluded. The patient met all six principal criteria of the JCS/JSCS 2020 guideline, leading to a diagnosis of complete KD. He received IVIG (2 g/kg) and oral aspirin (30 mg/kg/day, tapered after defervescence). Fever resolved within 24 h, followed by periungual desquamation. Transthoracic echocardiography showed a patent foramen ovale without coronary artery abnormalities, and repeat imaging at approximately 1 week and 1 month after onset confirmed normal coronary arteries with no evidence of aneurysms.ConclusionThis case illustrates that KD can emerge as a burn wound re-epithelializes, at which point the reappearance of fever is easily misattributed to an intercurrent infection. Across the present case and 13 previously reported, primary-source-verified cases, burn-associated KD occurred in children aged 5 years or younger, usually presented within about 2 weeks of the burn, mostly followed modest burns, and responded promptly to IVIG, with acute coronary artery changes observed in a minority (three of 14) that regressed after treatment. Whether burn injury triggers KD or the two co-occur by chance cannot be determined from a single case; the practical message is that clinicians should re-examine all mucocutaneous surfaces and consider KD in any pediatric burn patient with unexplained persistent fever, so that IVIG is not delayed.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1878171</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1878171</link>
        <title><![CDATA[Late-onset group B streptococcal septic arthritis in an afebrile neonate: a case report]]></title>
        <pubdate>2026-08-19T00:00:00Z</pubdate>
        <category>Case Report</category>
        <author>Asuman Akar</author>
        <description><![CDATA[The majority of neonatal group B streptococcal (GBS) infections present as sepsis or meningitis, while osteoarticular involvement is rare during the neonatal period. We report a case of culture-confirmed late-onset GBS septic arthritis in a 26-day-old male neonate presenting with progressive swelling, erythema, and irritability of the left knee without fever. Surgical irrigation and debridement revealed purulent arthritis. Because maternal prenatal records, maternal GBS screening status, and maternal infectious disease history were unavailable, a catheterized urine polymerase chain reaction (PCR) panel for sexually transmitted infections and genital tract-associated pathogens was obtained during the evaluation of a possible vertically or perinatally transmitted infection. The panel was positive for GBS on hospital day 0, approximately 72 h before joint tissue culture confirmation. Joint tissue culture subsequently yielded GBS, while blood and cerebrospinal fluid cultures remained sterile. The patient was treated successfully with intravenous ampicillin after initial empiric therapy with ampicillin and gentamicin. Clinical recovery and ultrasonographic resolution of joint effusion were achieved, and no clinical sequelae were detected at the 3-month post-discharge follow-up. This case emphasizes that afebrile neonates with progressive monoarticular swelling should be evaluated for septic arthritis and that definitive diagnosis relies on microbiological confirmation from a sterile-site specimen. The urine PCR finding, in this case, is reported as a hypothesis-generating observation in a neonate with unavailable maternal screening data; however, its biological significance remains uncertain and should not be interpreted as validation of urine PCR for invasive neonatal GBS disease or septic arthritis.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1809544</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1809544</link>
        <title><![CDATA[Development of a nomogram to predict acute liver injury in children with Mycoplasma pneumoniae pneumonia]]></title>
        <pubdate>2026-08-18T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Shisi Xiong</author><author>Yanlin Tan</author><author>Junmei Bian</author><author>Xingxing Bao</author><author>Jiajun Zhou</author><author>Min Liang</author>
        <description><![CDATA[ObjectiveTo construct and validate a nomogram for predicting acute liver injury in children with Mycoplasma pneumoniae pneumonia (MPP).MethodsThis retrospective study included 964 hospitalized children with confirmed MPP from January 2021 to December 2024. Acute liver injury was defined as the study endpoint. Missing data were handled by multiple imputation (m = 5). The cohort was divided into a training set and a validation set at a ratio of 7:3 using stratified random sampling. Least absolute shrinkage and selection operator (LASSO)-logistic regression was used for feature selection, and the selected variables were entered into multivariable logistic regression to construct a nomogram. Model performance was assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).ResultsAmong the 964 children, 131 developed acute liver injury, corresponding to an incidence of 13.6%. The cohort was divided into a training set of 676 children, including 92 with acute liver injury, and a validation set of 288 children, including 39 with acute liver injury. Baseline characteristics were comparable between the training and validation sets (P > 0.05). LASSO regression identified 11 candidate predictors: gender, age, body temperature ≥37.5 °C, history of allergy, neutrophil percentage, lymphocyte percentage, D-dimer, total protein, γ-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH), and creatine kinase isoenzyme MB (CK-MB). In multivariable analysis, female gender, GGT, LDH, and CK-MB were independently associated with an increased risk of liver injury, whereas age was negatively associated with liver injury. D-dimer showed marginal statistical significance. The nomogram showed good discrimination, with an area under the curve (AUC) of 0.837 in the training set and 0.874 in the validation set. Calibration curves showed acceptable agreement between predicted and observed risks, and DCA suggested potential clinical net benefit within a certain threshold range.ConclusionThis nomogram, based on routinely available clinical and laboratory indicators, may help identify children with MPP at increased risk of acute liver injury and support early liver function monitoring. Further prospective multicenter validation is needed.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1759723</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1759723</link>
        <title><![CDATA[Internet-Based home care education for children with pulmonary hypertension: a public health perspective]]></title>
        <pubdate>2026-08-18T00:00:00Z</pubdate>
        <category>Mini Review</category>
        <author>Yan Li</author><author>Juan Huang</author><author>Xuan Zhang</author><author>Yanhong Liu</author><author>Qingqing Song</author>
        <description><![CDATA[BackgroundPediatric pulmonary hypertension (PH) requires complex, specialized home care. Digital health interventions offer scalable solutions to address healthcare disparities, improve educational access, and reduce health system burdens while empowering caregivers.ObjectiveThis mini-review evaluates internet-based home care education for pediatric PH, focusing on public health implications, implementation strategies, and population-level outcomes.MethodsWe conducted a comprehensive narrative review of recent literature on internet-based education platforms and telehealth solutions for pediatric pulmonary hypertension, evaluating them through public health frameworks of accessibility, equity, and scalability.Key findingsInternet-based programs significantly improve medication adherence, complex skill acquisition (e.g., central line care), early symptom recognition, and caregiver self-efficacy. Effective platforms leverage multimodal learning, adaptive technologies, and interactive features. From a public health perspective, these interventions reduce preventable emergency department visits, lower long-term healthcare costs, and enhance quality of life. However, major barriers persist, including the digital divide, variable digital health literacy, and a lack of standardized content validation.ConclusionsInternet-based home care education is vital for pediatric PH management. Future efforts must prioritize standardized, evidence-based curricula, health equity across socioeconomic strata, digital health reimbursement policies, and integration into existing public health infrastructure to maximize population-level benefits.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1963583</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1963583</link>
        <title><![CDATA[Editorial: Exploring child abuse from clinical, legal, and forensic perspectives]]></title>
        <pubdate>2026-08-18T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Donato Morena</author><author>Emanuela Turillazzi</author><author>Vittorio Fineschi</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1908007</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1908007</link>
        <title><![CDATA[Palliative care for children with cancer in Cuba: a narrative review and adaptation of the World Health Organization integration model]]></title>
        <pubdate>2026-08-18T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Mariuska Forteza Sáez</author><author>Maria del Carmen Llantá Abreu</author><author>Yolainy Romero Rodríguez</author><author>Dayne Clarivel Quintero Vázquez</author>
        <description><![CDATA[BackgroundPalliative care for children with cancer represents an urgent health priority in Cuba. The country has a universal and free health system with national coverage, but the systematic provision of specialized pediatric palliative care (PPC) in oncology remains heterogeneous, with significant gaps across the eight pediatric oncology reference centers.ObjectiveTo describe the state of PPC development for children with cancer in Cuba, analyze it through the lens of the simultaneous integration model proposed by the World Health Organization (WHO), and identify gaps and opportunities for strengthening. This review is intentionally limited to pediatric oncology; PPC needs of children with non-oncological life-limiting conditions fall outside its scope.MethodsNarrative review of scientific literature published between 2000 and 2024, normative documents of the Cuban Ministry of Public Health (MINSAP), and reports from international organizations (WHO, PAHO, IAHPC, ALCP). Two authors independently screened identified records; disagreements were resolved by discussion with a third author. The WHO analytical framework for PPC integration was applied to evaluate six key dimensions: policy, education, medicines, services, research, and financing.ResultsCuba has a solid normative basis for PPC, including Ministerial Resolution No. 261/2020 and the National Cancer Control Program. Primary care coverage is universal, and the family doctor system facilitates care continuity, though the current level of formal PC training among family physicians specifically has not been systematically documented. Gaps were identified in: specialized staff training, equitable access to opioids at home, formal constitution of PPC teams in all eight centers, and published clinical research on outcomes in this population.ConclusionsCuba has favorable structural conditions for implementing an integrated, high-quality PPC model for children with cancer. The implementation of the National Pediatric Palliative Care Project 2026–2028 represents an important opportunity. Explicit alignment with the WHO model, strengthening specialized training, and generation of national scientific evidence are recommended.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fped.2026.1863943</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fped.2026.1863943</link>
        <title><![CDATA[Breastfeeding difficulties and maternal–infant bonding at three months postpartum in a Turkish cohort]]></title>
        <pubdate>2026-08-18T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Bulent Gunes</author><author>Ferit Dogan</author><author>Ahmet Guzelcicek</author><author>Aydin Bozkaya</author><author>S. Songul Yalcin</author>
        <description><![CDATA[BackgroundBreastfeeding difficulties are common in the early postpartum period and have been hypothesized to negatively affect maternal–infant bonding. We aimed to investigate the relationship between breastfeeding problems and mother–infant bonding at 3 months postpartum in a sample of Turkish mothers.MethodsWe conducted a cross-sectional observational study of 257 mothers of 3-month-old infants in Turkey. Participants completed a questionnaire including demographic and obstetric information, breastfeeding practices and difficulties, and the Postpartum Bonding Questionnaire (PBQ) to assess maternal–infant bonding. Bonding difficulty was defined as a PBQ total score >25. Bivariate analyses (chi-square or Fisher's exact tests) compared mothers with and without bonding difficulties, and a multivariable logistic regression model was used to identify independent predictors of bonding problems at 3 months postpartum.ResultsOverall, 33 mothers (12.8%) met criteria for bonding difficulties at 3 months. A total of 144 mothers (56.0%) reported at least one breastfeeding problem during the first 3 months postpartum. In bivariate analyses, breastfeeding difficulties were more common among mothers with bonding difficulties than among those without (81.8% vs. 52.2%, P = .001). Mothers with bonding difficulties were also more likely to have higher education (81.8% vs. 54.9% with ≥ secondary education; P = .003), to be employed outside the home (21.2% vs. 8.9%; P = .06), and to have a female infant (66.7% vs. 38.8% female; P = .003). No significant differences were found by maternal age, parity, or feeding mode (exclusive breastfeeding vs. formula feeding, P = .64). In multivariable logistic regression, breastfeeding difficulties were independently associated with bonding impairment (adjusted odds ratio [OR] 3.5, 95% confidence interval [CI] 1.5–8.0, P = .003). Maternal higher education (adjusted OR 3.0, 95% CI 1.1–8.0, P = .031) and having a female infant (adjusted OR 3.1, 95% CI 1.2–7.5, P = .016) were also independent predictors; maternal employment showed a positive but non-significant association (adjusted OR 2.2, 95% CI 0.9–5.5, P = .081).ConclusionsIn this Turkish sample, mothers who reported breastfeeding difficulties had higher odds of impaired maternal–infant bonding at 3 months postpartum. These findings support routine assessment of breastfeeding-related distress during postpartum care.]]></description>
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