AUTHOR=Korotkova Marina , Jakobsson Per J.

TITLE=Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 1 - 2010

YEAR=2011

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2010.00146

DOI=10.3389/fphar.2010.00146

ISSN=1663-9812

ABSTRACT=Microsomal prostaglandin E synthase-1 (mPGES-1) is a well recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding of mPGES-1 in rheumatoid arthritis, osteoarthritis and inflammatory myopathies. Novel findings regarding regulation of mPGES1 cell expression as well as enzyme inhibitors are also summarized.