AUTHOR=Pyne Nigel J., Pyne Susan 

TITLE=Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

JOURNAL=Frontiers in Pharmacology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2011.00026

DOI=10.3389/fphar.2011.00026

ISSN=1663-9812

ABSTRACT=<p>A recent perspective published in <italic>Frontiers of Pharmacology</italic> by Salomone and Waeber (<xref ref-type="bibr" rid="B27">2011</xref>) discussed the selectivity and specificity of sphingosine 1-phosphate (S1P) receptor ligands. This perspective surveyed the use of various S1P receptor ligands and attempted to reconcile a number of inconsistencies in the predicted biological outcomes: these were interpreted as “off-target” effects. Therefore the perspective cautioned against the use of these S1P receptor ligands. Here we highlight the complex pharmacology of S1P receptors, which along with “inside-out” signaling might provide an alternative explanation for “off-target” effects.</p>