AUTHOR=Zhu Xiao L., Liu Ji H., Li Wei D., Lin Zhi B.

TITLE=Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides

JOURNAL=Frontiers in Pharmacology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2012.00020

DOI=10.3389/fphar.2012.00020

ISSN=1663-9812

ABSTRACT=<p>Our previous studies demonstrated that <italic>Ganoderma lucidum</italic> polysaccharides (<italic>Gl</italic>-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. To investigate the possible mechanism by which <italic>Gl</italic>-PS promote myelopoiesis during myelosuppression induced by cyclophosphamide, mice were injected intraperitoneally (i.p.) once daily with 2.5 mg/kg of <italic>Gl</italic>-PS for 10 days and were treated i.p. once daily with cyclophosphamide (100 mg/kg) on days 2 through 4. In the present study <italic>in vivo</italic> and <italic>in vitro</italic>, we find that <italic>Gl</italic>-PS selectively bind to bone marrow stromal cells, stimulate the secretion of hematopoietic growth factors, and enhance the clonogenic activities of hematopoietic and stromal cells to promote hematopoiesis in myelosuppressed mice.</p>