AUTHOR=Kuse Yoshiki , Tsuruma Kazuhiro , Kanno Yusuke , Shimazawa Masamitsu , Hara Hideaki TITLE=CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure JOURNAL=Frontiers in Pharmacology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00207 DOI=10.3389/fphar.2017.00207 ISSN=1663-9812 ABSTRACT=
The C-C chemokine receptor type 3 (CCR3) is the receptor for eotaxins (CCL-11, 24, 26), RANTES (CCL-5) and MCP-3 (CCL-7). It was reported that an inhibition of CCR3 by antagonists or antibodies reduces the degree of laser-induced choroidal neovascularization in mice, a model for wet age-related macular degeneration (AMD). Although several chemokine receptors have the potential of reducing the degree of the chronic inflammation in experimental dry AMD, the association of CCR3 remains unknown. The purpose of this study was to determine the role played by CCR3 in the death of 661W cells which are cells of a murine photoreceptor-derived cell line as an