AUTHOR=Chi Huju , Li Chunman , Zhao Flora Sha , Zhang Li , Ng Tzi Bun , Jin Guangyi , Sha Ou 

TITLE=Anti-tumor Activity of Toll-Like Receptor 7 Agonists

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00304

DOI=10.3389/fphar.2017.00304

ISSN=1663-9812

ABSTRACT=Toll like receptors (TLRs) are a class of pattern recognition receptors that play a bridge role in the innate immunity and adaptive immunity. The activated TLRs not only induce inflammatory responses, but also lead to the development of antigen specific immunity. TLR7, a member of TLR family, is an intracellular receptor expressed on the membrane of endosomes, and its powerful immune stimulatory action can be potentially used in the anti-tumor therapy. This article reviews the anti-tumor activities of the agonists of TLR7, which are frequently applied in the preclinical and clinical investigations.