AUTHOR=Meurer Steffen K. , Weiskirchen Ralf TITLE=Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition! JOURNAL=Frontiers in Pharmacology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00098 DOI=10.3389/fphar.2018.00098 ISSN=1663-9812 ABSTRACT=

We have identified a phenomenon occurring in the usage of proposed “specific” Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation of all former studies using MAPK inhibitors.