AUTHOR=Cheng Xiao-Yu , Liu Jun-Da , Lu Xin-Yi , Yan Xing , Huang Cheng , Meng Xiao-Ming , Li Jun TITLE=miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1 JOURNAL=Frontiers in Pharmacology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00275 DOI=10.3389/fphar.2018.00275 ISSN=1663-9812 ABSTRACT=
Alcoholic liver disease (ALD) is a global liver disease which characterized by liver inflammation, fatty liver, alcoholic hepatitis, or liver cirrhosis. Alcohol abuse is one of the main reasons for liver disease. Alcoholic fatty liver (AFL) disease is the early stage of ALD and associated with the excessive lipids accumulation in hepatocytes as well as oxidative stress. MicroRNA-203 (miR-203) is known to suppress the proliferation and metastasis of hepatocellular carcinoma, but the role in the progression of alcoholic liver disease is not clear and is warranted for further investigation. In the present study, we have found the expression of miR-203 is down-regulated in Gao-Binge alcoholic mice model and ethanol-induced AML-12 cell lines