AUTHOR=Yang Xinyu , Liu Nian , Li Xinye , Yang Yihan , Wang Xiaofeng , Li Linling , Jiang Le , Gao Yonghong , Tang Hebin , Tang Yong , Xing Yanwei , Shang Hongcai 

TITLE=A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00444

DOI=10.3389/fphar.2018.00444

ISSN=1663-9812

ABSTRACT=Anthracyclines are effective agents generally used to treat solid-tumor malignancies and hematologic malignancies. The widely use of anthracyclines for over 40 years has quite improved cancer survival statistics. Nevertheless, clinical utility is restricted by dose-dependent cardiotoxicity that adversely affects 10%-30% of patients. Anthracyclines-induced cardiotoxicity may be sorted as acute/subacute or chronic/late toxicity, becoming a devastating adverse effect resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese Medicine, has a history of over 2,000 years, with both unique theories and ample experience. Several studies have researched the potential of natural products in decreasing the cardiotoxicity effects of chemotherapeutic agents on healthy cells, while unaffected their antineoplastic activity. This article discusses the mechanism of anthracyclines-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment on anthracyclines-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia Chinesein recent years, in order to provide a reference for clinical prevention and treatment of cardiac toxicity.