AUTHOR=Leonti Marco , Casu Laura 

TITLE=Ethnopharmacology of Love

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00567

DOI=10.3389/fphar.2018.00567

ISSN=1663-9812

ABSTRACT=Background: Elixirs conferring eternal youth or inducing amatory and erotic attraction have been searched for through history without success. Lovesickness is a widespread affliction resulting from unrequited love and/or the impossibility for physical and emotional union. The symptoms are reflections of altered dopamine, serotonin, noradrenaline, testosterone and cortisol levels and range from frenzy and intrusive thinking to despair and depression sharing traits with neurochemistry of addiction and compulsive behavior disorder. Although it can seriously impact the quality of life, lovesickness is currently not considered by the official disease classification systems. Consequently, no official therapeutic guidelines exist leaving subjects to seek the cure by their own. 
Methods: We review literature dealing with the concept, diagnosis and the healing of lovesickness of the past 2000 years and contextualize it with neurochemical ethnomedical and ethnographic data. Since neurobiological and pharmacological connections between the love and the sex drive exist, we review also the literature about herbal an- and aphrodisiacs focusing on their excitatory or calmative potential. 
Results: An overall consensus for dealing with lovesickness from historical until contemporary literature exits regarding socio-behavioral regimes. The herbal drugs used for treating lovesickness or induce love passion do not have the alleged properties. The pharmacological interactions of aphrodisiacs are heterogeneous including dopaminergic and adrenergic activities but there is no evidence for any serotonergic effect. The libido regulating effects of anaphrodisiacs seem to be associated with sedative and toxic properties or decreasing testosterone levels. CB2 receptors expressed on dopaminergic neurons of the ventral tegmental area, part of the brain’s reward circuit also implicated with addiction, orgasm and strong emotions such as love, might constitute a new therapeutic target. 
Conclusions: The common food additive and CB2 agonist β-caryophyllene might have the potential to attenuate dopaminergic firing, quenching the reward and thus motivation associated with romantic love. From Greek mythology to modern history cultural expression and implication of love, sex and procreation is and was organized along hierarchical lines putting men on top. The neuronal predispositions and activities associated with falling in love will probably remain nature’s and Eros’ secret forever.