AUTHOR=Hendrickx Jhana O. , van Gastel Jaana , Leysen Hanne , Santos-Otte Paula , Premont Richard T. , Martin Bronwen , Maudsley Stuart 

TITLE=GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01484

DOI=10.3389/fphar.2018.01484

ISSN=1663-9812

ABSTRACT=Complex aging triggered disorders are multifactorial programs that comprise multiple alterations in interconnected protein networks over a large range of tissues. To coordinate the generation of these pathological events, it is evident that rather than being randomly organized pathophysiologies that possess a strong aging component such as cardiovascular diseases (hypertensions, atherosclerosis and vascular stiffening) and neurodegenerative conditions (dementia, Alzheimers disease, mild cognitive impairment, Parkinsons disease), they represent a modified version of the intricate molecular aging programs already in place. To control such multidimensional functions there are layers of trophic protein control across these networks mediated by keystone proteins. These proteins interact and regulate multiple signaling pathways to engender a whole somatic phenotype, here we posit that the G protein coupled receptor kinase 5 (GRK5) represents one of these key controllers. Considerable data has emerged, suggesting that GRK5 acts as a bridging factor, allowing signaling regulation in pathophysiological settings to control both the cardiovascular and neurophysiological complications of aging.