AUTHOR=Shou Qiyang , Jin Lu , Lang Jiali , Shan Qiyuan , Ni Zhunan , Cheng Changpei , Li Qinglin , Fu Huiying , Cao Gang 

TITLE=Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 9 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01531

DOI=10.3389/fphar.2018.01531

ISSN=1663-9812

ABSTRACT=Asthma is a chronic airway inflammatory disease, which is characterized by airway remodeling, hyperreactivity and short of breath. Paeoniflorin is one of the major active ingredients in Chinese peony, which exerts anti-inflammatory and immune-regulatory effects in multiple diseases. However, it remains unclear about whether paeoniflorin treatment can suppress allergic asthma. In this study, we had evaluated the effect of paeoniflorin on the lung function and airway inflammation in asthmatic mice. These asthmatic Balb/c mice were first sensitized and constructed through ovalbumin motivation. Subsequently, we had determined the mechanism of action of paeoniflorin on treating allergic asthma through the integrated transcriptomic and metabolomic data sets. Our results discovered that many genes and metabolites were regulated in the paeoniflorin-treated mice. Moreover, the potential target proteins of paeoniflorin played important roles in fatty acid metabolism, inflammatory response, oxidative stress and local adhesion. In conclusion, paeoniflorin shows beneficial effect on asthma, which may be achieved through regulating fatty acid metabolism, inflammatory response and the adhesion pathway at system level.