AUTHOR=Xiao Xiao , Wang Ting , Li Leijiao , Zhu Zhongli , Zhang Weina , Cui Guihua , Li Wenliang 

TITLE=Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00110

DOI=10.3389/fphar.2019.00110

ISSN=1663-9812

ABSTRACT=A strategy for preparing composite micelles containing both cisplatin(IV) (CisPt(IV)) prodrug and capecitabine using a co-assembly method is described in this study. The composite micelles are capable of an effective release of the anticancer drug cisplatin(II) (CisPt(II)) and capecitabine via acid hydrolysis once they are internalized by cancer cells. Moreover, the composite micelles display a synergistic effect in vitro and the combination therapy in the micellar dosage form leads to reduced systemic toxicity and enhanced antitumor efficacy in vivo.