AUTHOR=Zhang Jiayu , Zhao Tiancheng , Tian Leilei , Li Yezhou 

TITLE=LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00449

DOI=10.3389/fphar.2019.00449

ISSN=1663-9812

ABSTRACT=Hemangioma, which is a benign vascular neoplasm, has been demonstrated to be the most common tumor of infancy, resulting from aberrant proliferation of endothelial cells and pericytes. The aim of current study was to determine the role of lncRNA OIP5-AS1 on proliferation and metastasis of human hemangioma endothelial cell (HemECs). In this study, we examined the expression of OIP5-AS1 and miR-195-5p in hemangiomas patients. The effects of ectopic expression of OIP5-AS1 on the viability, proliferation, cell cycle distribution, and apoptosis of HemECs were explored. Rescue assays were performed to explore the effect of OIP5-AS1/miR-195-5p/NOB1 axis on biological behaviors in the HemECs. It was found that OIP5-AS1 was overexpressed in both hemangioma tissues and HemECs cells. OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell. LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate STAT3 in HemECs cell. Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs cells through regulating miR-195-5p/STAT3 axis.