AUTHOR=Li Jia-jun , Yan Yan-yan , Sun Hong-mei , Liu Yun , Su Chao-yue , Chen Hu-biao , Zhang Jian-ye 

TITLE=Anti-Cancer Effects of Pristimerin and the Mechanisms: A Critical Review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00746

DOI=10.3389/fphar.2019.00746

ISSN=1663-9812

ABSTRACT=As a a quinonemethide triterpenoid extracted from species of the Celastraceae and Hippocrateaceae, pristimerin has been shown to have potent anti-cancer effects. Specifically, it was found that pristimerin can affect many tumor-related processes including vasculogenesis, autophagy, epithelial-mesenchymal transition and ubiquitin-proteasomal degradation, as well as involving various molecular targets and signaling pathways such as cyclins, reactive oxygen species  caspase-3, and NF-κB, MAPK/ERK and AKT/mTOR pathways. In this review, we will focus on the the research about anti-cancer effacy of pristimerin to achieve a deeper understanding of the targets and mechanisms, which offers evidences suggesting that pristimerin can be a potent anti-cancer drug.