AUTHOR=Xin Ning , Fen Zhou , Li Cheng , Yan Xiao , Runming Jin 

TITLE=Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01072

DOI=10.3389/fphar.2019.01072

ISSN=1663-9812

ABSTRACT=A 11-year-old male patient with IKZF1 deletion and BCR-ABL1-positive acute lymphoblastic leukemia appeared elevated levels of serum alanine aminotransferase and cholecystitis with the symptoms of vomiting, abdominal pain and diarrhea during the first course of high-dose methotrexate. He was admitted for myelosuppression, oral mucositis, rashes and dysfunction of liver during the second treatment of high-dose methotrexate. At last, intracranial hemorrhage occurred following oral methotrexate at doses of 25mg/m2, and CT scan of his brain showed increased intensities in multiple cerebral lobes. he had neurological sequelae of hemiplegic paralysis after six months.