AUTHOR=Wei Xia , Zhu Qingfen , Liu Na , Xu Lihua , Wei Sheng , Fan Zhiyun , Sun Changhua , Zhao Yan , Qiao Mingqi , Wu Jibiao , Hu Defu , Wang Yang , Sun Peng 

TITLE=Neuroprotective Effects and Mechanisms of Zhenlong Xingnao Capsule in In Vivo and In Vitro Models of Hypoxia

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01096

DOI=10.3389/fphar.2019.01096

ISSN=1663-9812

ABSTRACT=Zhenlong Xingnao Capsule (ZXC) is a Tibetan medicine used to treat ischemic stroke. We aimed to clarify the role of ZXC in cerebral ischemia protection; reveal amino acid neurotransmitter changes in the frontal cortex after drug intervention; determine mRNA and protein expression changes in Bcl-2, Bax, caspase-3, P38, and nuclear factor (NF)-кB in the frontal cortex and changes in antioxidant indices in the brain; and elucidate the mechanisms underlying ZXC action.