AUTHOR=Bai Jing , Wang Chunming TITLE=Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00407 DOI=10.3389/fphar.2020.00407 ISSN=1663-9812 ABSTRACT=
Organoids are adept at preserving the inherent complexity of a given cellular environment and when integrated with engineered micro-physiological systems (MPS) present distinct advantages for simulating a precisely controlled geometrical, physical, and biochemical micro-environment. This then allows for real-time monitoring of cell-cell interactions. As a result, the two aforementioned technologies hold significant promise and potential in studying ocular physiology and diseases by replicating specific eye tissue microstructures