AUTHOR=Wang Jiaolong , Zhan Lilin , Zhang Xianhua , Wu Runfa , Liao Lan , Wei Junchao 

TITLE=Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00431

DOI=10.3389/fphar.2020.00431

ISSN=1663-9812

ABSTRACT=Bacterial infection has been a critic problem for implant infections. Poly(L-lactide) (PLLA) membrane has great potential for Guided bone regeneration (GBR), however, PLLA lack antibacterial properties and thus may face bacterial infections. In this work, a mussel inspired method was used to treat PLLA membrane with dopamine and formed poly(dopamine) (PDA) coated PLLA(PLLA@PDA), and then silver Nanoparticles (AgNPs) was immobilized on the surface of PLLA via the reduction effect of PDA. The antibacterial test showed that the Ag NPs coated PLLA (PLLA@Ag) have good antibacterial properties, besides, the composite membrane have good biocompatibility, implying that the PLLA@Ag membrane have potential applications as antibacterial GBR membrane.