AUTHOR=Toro Mario D. , Nowakowska Dominika , Brzozowska Agnieszka , Reibaldi Michele , Avitabile Teresio , Bucolo Claudio , Murabito Paolo , Chisari Clara , Nowomiejska Katarzyna , Rejdak Robert 

TITLE=Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00440

DOI=10.3389/fphar.2020.00440

ISSN=1663-9812

ABSTRACT=Purpose: To assess the pain intensity of two intraocular solutions in patients undergoing cataract surgery and evaluate the factors influencing the patients’ postoperative activities. 
Methods: Sixty-two patients undergoing cataract surgery were randomized to receive Mydrane or a solution of 1% lidocaine and 0.025% of adrenaline as an intraocular anesthetic. The pain intensity was assessed by Visual Analog Scale for Pain (VAS Pain) and Brief Pain Inventory-short form (BPI) on the next day after the surgery.
Results: The mean pain score measured preoperatively with VAS Pain was 0.34 in Mydrane group and 0.09 in the reference group (p=0.51). There were no statistically significant differences between the two anesthetic methods with respect to pain intensity during the surgery (p=0.94) and the influence of pain during the last 24 h on activity (p=0.79), mood (p=0.31), social contacts (p=0.29), sleep (p=0.5) and the joy of life (p=0.39). Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases (p=0.98) and post-operative complications (p=0.4) on the experienced pain measured during the surgery and in the last 24 h.
Conclusions: Intraocular anesthesia during the cataract surgery using Mydrane seems to be as effective as the solution of 1% lidocaine with 0.025% adrenaline.