AUTHOR=Ahmad Baseer , Li Zhongxuan , Hanif Quratulain , Hu Qingyong , Wei Xubiao , Zhang Lulu , Khan Shahzad Akbar , Aihemaiti Maierhaba , Gulzar Huma , Shahid Muhammad , Si Dayong , Zhang Rijun TITLE=A Hybrid Peptide DEFB-TP5 Expressed in Methylotrophic Yeast Neutralizes LPS With Potent Anti-inflammatory Activities JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00461 DOI=10.3389/fphar.2020.00461 ISSN=1663-9812 ABSTRACT=
DEFB-TP5 is a novel auspicious health-beneficial peptide derivative from two naturally occurring peptides, β-Defensin (DEFB) and thymopentin (TP5), and shows strong anti-inflammatory activity and binds to LPS without cytotoxicity and hemolytic effect. Furthermore, the application of DEFB-TP5 peptide is inadequate by its high cost. In the current study, we developed a biocompatible mechanism for expression of the DEFB-TP5 peptide in