AUTHOR=Lattuada Enrico , Leo Manuela , Caprara Debora , Salvatori Luisa , Stoppacciaro Antonella , Sciortino Francesco , Filetici Patrizia 

TITLE=DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.01345

DOI=10.3389/fphar.2020.01345

ISSN=1663-9812

ABSTRACT=Novel DNA materials promise unpredictable perspectives for applications in cell biology. The realization of DNA-hydrogels built by a controlled association of DNA nanostars, whose binding can be tuned with minor changes in the nucleotide sequences, has been recently described. Such novel nanomaterials with tailored and unusual gelation properties can be successfully employed for in situ delivery of drugs and bioactive molecules in tissues. We provide here a comprehensive description of different, recently realized DNA-gels with the perspective of stimulating their application to biological systems and cell lines. Finally, we discuss the possibility to design sophisticated 3D tissue-like DNA-gels incorporating cell spheroids or single cells for the assembly of a novel kind of cellular matrix and as a preclinical investigation for the implementation of tools for in vivo delivery of bioactive molecules.