AUTHOR=Ding Qian , Shao Chunhong , Rose Peter , Zhu Yi Zhun 

TITLE=Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.535395

DOI=10.3389/fphar.2020.535395

ISSN=1663-9812

ABSTRACT=Epigenetics is defined as heritable alterations of gene expression without changing the DNA sequence, it is mainly including DNA methylation, histone modifications, and non-coding RNAs mechanisms. Vascular aging containing both structural and functional changes in vascular and a few pathological processes are involved in the progress, such as vascular cell senescence, widespread inflammation or oxidation stress and calcification. With the increase of age, people affected by the environment are gradually accumulating, compared with genetic factors, epigenetic regulation plays a more important role in the aging-related diseases, and drugs targeting epigenetic regulation are expected to be novel treatment strategies for age-related diseases. In our previous studies, we found HDAC4, JMJD3, Fra-1, GATA4 and Smyd family might be very interesting potential pharmacological sites for regulating vascular inflammation, injury, and senescence.