AUTHOR=Srivastava Swayam Prakash , Kanasaki Keizo , Goodwin Julie E. 

TITLE=Loss of Mitochondrial Control Impacts Renal Health

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.543973

DOI=10.3389/fphar.2020.543973

ISSN=1663-9812

ABSTRACT=Disruption of mitochondrial biosynthesis or in mitochondrial dynamics or loss of control over mitochondrial regulation leads to a significant alteration in fuel preference and metabolic shifts that potentially affect the health of kidney cells. Mitochondria regulate metabolic network which affect multiple cellular processes.  Indeed, mitochondria have established themselves as a therapeutic target in several diseases. The importance of mitochondria in regulating pathogenesis of several diseases has been recognized, however, there is limited understanding of mitochondrial biology in kidney.  This review highlights  an overview of the mitochondrial dysfunctions in kidney diseases. We describe the importance of mitochondria, and mitochondrial sirtuins in regulation of renal metabolic shifts in diverse cells types, and loss of control leads to increased cell-to-cell transdifferenciation processes and myofibroblast-metabolic shifts, which affect pathophysiology of several kidney diseases. In addition, we examine the mitochondrial-targeted therapeutic agents that offers potential leads in combating kidney diseases.