AUTHOR=Sharifi-Rad Javad , Kamiloglu Senem , Yeskaliyeva Balakyz , Beyatli Ahmet , Alfred Mary Angelia , Salehi Bahare , Calina Daniela , Docea Anca Oana , Imran Muhammad , Anil Kumar Nanjangud Venaktesh , Romero-Román Maria Eugenia , Maroyi Alfred , Martorell Miquel 

TITLE=Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.571459

DOI=10.3389/fphar.2020.571459

ISSN=1663-9812

ABSTRACT=Compilating the most relevant studies of psoralidin, a coumarin from seeds of Cullen corylifolium (L.) Medik. (syn. Psoralea corylifolia L.), has recently confirmed this compound display interesting pharmacological properties. Last years, interest in this compound had been changed and take it up due to its widespread beneficial for estrogen-related diseases and as a chemopreventive agent. A growing number of preclinical evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with underlying the molecular mechanisms and cell signaling pathways. In the light of these beneficial actions for human health of psoralidin, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.