AUTHOR=Wang Yuwei , Tang Shuai , Lai Huanling , Jin Ruyi , Long Xu , Li Na , Tang Yuping , Guo Hui , Yao Xiaojun , Leung Elaine Lai-Han 

TITLE=Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.579768

DOI=10.3389/fphar.2020.579768

ISSN=1663-9812

ABSTRACT=IDH1 mutation occurs in 20–30% of gliomas and is a promising target for the cancer therapy. In present study, the performances of the different IDH1R132H were verified by using glide-docking-based virtual screening. Based on the two crystal structures (5TQH and 6B0Z) with the best capability to distinguish IDH1 inhibitors from decoys, a docking-based virtual screening was employed for identified novel IDH1R132H inhibitors. A total of 57 structurally diverse compounds were reserved and evaluated with experimental testing, and 10 of them exhibited substantial activity against the IDH1R132H (IC50 < 50 μM). Molecular docking technology showed that L806-0255, V015-1671 and AQ-714/41674992 could bind to the binding pocket composed of hydrophobic residues. These findings indicate that L806-0255, V015-1671 and AQ-714/41674992 have the potential for further optimization as a lead compound for the treatment of IDH1 mutated gliomas.