AUTHOR=Wang Ke , Zhang Beibei , Song Dingzhong , Xi Jianqiang , Hao Wusi , Yuan Jie , Gao Chenyu , Cui Zhongbao , Cheng Zhihong 

TITLE=Alisol A Alleviates Arterial Plaque by Activating AMPK/SIRT1 Signaling Pathway in apoE-Deficient Mice

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.580073

DOI=10.3389/fphar.2020.580073

ISSN=1663-9812

ABSTRACT=Alismatis Rhizoma (zexie), an herb used in traditional Chinese medicine, exhibits hypolipemic, anti-inflammation and anti-atherosclerotic activities. Alisol A is one of the main active ingredients in Alismatis Rhizoma extract. In this study, we investigate the role of alisol A in anti-atherosclerosis. Our study demonstrated that alisol A can effectively inhibit the formation of arterial plaques and blocked the progression of atherosclerosis in ApoE -/-mice fed with high-fat diet. and significantly reduced the expression of inflammatory cytokins in aorta, including ICAM-1, IL-6 and MMP-9.