AUTHOR=Wei Wumei , Ao Qiang , Wang Xiaohong , Cao Yue , Liu Yanying , Zheng Song Guo , Tian Xiaohong 

TITLE=Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.590470

DOI=10.3389/fphar.2020.590470

ISSN=1663-9812

ABSTRACT=As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes have been studied in the diagnosis, prevention and treatment of many diseases, especially exosomes derived from mesenchymal stem cells (MSC-exosomes). Meanwhile, through the combination of nanotechnology and biotechnology, exosomes have emerged as innovative tools for the development of nanomedicine. This review focuses on a profound summarization of MSC-exosomes as a powerful tool in bionanomedicine. It systemically summarized the role of MSC-exosomes as nanocarrier, drug loading and tissue engineering, and their potential contribution in a series of diseases, as well as the advantages of exosomes over stem cells and synthetic nanoparticles, and potential disadvantages. The in-depth understanding of the functions and mechanisms of exosomes provides insights into the basic research and clinical transformation in the field of nanomedicine.