AUTHOR=Zhou Nan-Qian , Fang Zhi-Xin , Huang Ning , Zuo Yue , Qiu Yue , Guo Li-Juan , Song Ping , Xu Jian , Wan Guang-rui , Tian Xin-Qiao , Yin Ya-ling , Li Peng 

TITLE=aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.607785

DOI=10.3389/fphar.2021.607785

ISSN=1663-9812

ABSTRACT=The purpose of this study was to evaluate the protective effect of acidic fibroblast growth factor targeted mediated by novel nanoparticles-cationic lipid microbubbles complex (aFGF-NP+CPMBs) combined with ultrasound targeted microbubble destruction(UTMD) on doxorubicin-induced heart failure（HF）and its mechanism.Heart failure rats induced by intraperitoneal injection with doxorubicin(DOX) to achieve cumulative dose of 15mg/kg for continuous six weeks showed left ventricular dysfunction,seriously oxidative stress and cardiomyocyte apoptosis and decrease of myocardial vascular density.In contrast, aFGF-NP+CPMBs combined with UTMD therapy(3ug/kg,caudal vein injection,twice a week,six weeks）prominently ameliorated left ventricular dysfunction by increased ejection fraction(EF) and fractional shortening(FS),decreased brain natriuretic peptide (BNP);strengthened the ability of antioxidant stress confirmed by increasing the activity of SOD and reducing the production of MDA;exerted the effect of anti-cardiomyocyte apoptosis and promotion angiogenesis by inhibited Bax expression and increased Bcl-2 expression and platelet endothelial cell adhesion molecule (CD31) expression.Taken together,the research suggested that aFGF targeted mediated by novel nanoparticles-cationic lipid microbubbles complex combined with UTMD should be a promising targeted treatment for heart failure.