AUTHOR=Ghiciuc Cristina Mihaela , Shleghm Maytham Razaq , Vasile Cornelia , Tantaru Gladiola , Creteanu Andreea , Ochiuz Lacramioara 

TITLE=Study on Acute Toxicity of Amiodarone New Complexes With Cyclodextrin

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.640705

DOI=10.3389/fphar.2021.640705

ISSN=1663-9812

ABSTRACT=Amiodarone low solubility and high permeability is the limiting step for its bioavailability, therefore new formulations are needed to increase its oral bioavailability Complexation of Amiodarone with Cyclodextrin results in improved dissolution rate, solubility and bioavailability and allows for a more controlled drug release. We characterized the acute toxicity of a new Amiodarone cyclodextrin complex, administered orally in laboratory animals.