AUTHOR=Cereta Andressa Daronco , Oliveira Vinícius Rosa , Costa Ivan Peres , Afonso João Pedro Ribeiro , Fonseca Adriano Luís , de Souza Alan Robson Trigueiro , Silva Guilherme Augusto Moreira , Mello Diego A. C. P. G. , Oliveira Luis Vicente Franco de , da Palma Renata Kelly TITLE=Emerging Cell-Based Therapies in Chronic Lung Diseases: What About Asthma? JOURNAL=Frontiers in Pharmacology VOLUME=Volume 12 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.648506 DOI=10.3389/fphar.2021.648506 ISSN=1663-9812 ABSTRACT=

Asthma is a widespread disease characterized by chronic airway inflammation. It causes substantial disability, impaired quality of life, and avoidable deaths around the world. The main treatment for asthmatic patients is the administration of corticosteroids, which improves the quality of life; however, prolonged use of corticosteroids interferes with extracellular matrix elements. Therefore, cell-based therapies are emerging as a novel therapeutic contribution to tissue regeneration for lung diseases. This study aimed to summarize the advancements in cell therapy involving mesenchymal stromal cells, extracellular vesicles, and immune cells such as T-cells in asthma. Our findings provide evidence that the use of mesenchymal stem cells, their derivatives, and immune cells such as T-cells are an initial milestone to understand how emergent cell-based therapies are effective to face the challenges in the development, progression, and management of asthma, thus improving the quality of life.