AUTHOR=Meng Miaomiao , Zhang Lijuan , AI Di , Wu Hongyun , Peng Wei 

TITLE=β-Asarone Ameliorates β-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.659955

DOI=10.3389/fphar.2021.659955

ISSN=1663-9812

ABSTRACT=Accumulation of β-amyloid (Aβ) causes oxidative stress, which is the major pathological mechanism in Alzheimer’s disease (AD). β-asarone could reduce Aβ-induced oxidative stress and neuronal damage, but the molecular mechanism remains elusive. In this study, we used Aβ-stimulated PC12 cells model to explore the neuroprotective effects and potential mechanisms of β-asarone. The results showed β-asarone could improve cell viability and weaken cell damage and apoptosis. β-asarone also could decrease the level of ROS and MDA, increase the level of SOD, CAT and GSH-PX and ameliorate the mitochondrial membrane potential. Furthermore, β-asarone could promote the expression of Nrf2 and HO-1 by upregulating the level of PI3K/Akt phosphorylation. In conclusion, β-asarone could exert neuroprotective effects by modulating P13K/Akt/Nrf2 signaling pathway. β-asarone might be a promising therapy for AD.