AUTHOR=McEvoy L. , Carr D. F. , Pirmohamed M. 

TITLE=Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.684162

DOI=10.3389/fphar.2021.684162

ISSN=1663-9812

ABSTRACT=Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of anti-inflammatory analgesics which are widely used globally for the treatment of pain and inflammation.  Chronic NSAID use is associated with potentially serious gastrointestinal (GI) adverse drug reactions (ADRs). Genetic-based risk factors have been identified, serving as predictors of adverse GI events including peptic ulcer disease (PUD) and upper gastrointestinal bleeding (UGIB). Opportunities to exploit contradictory findings and knowledge gaps, including a lack of clear clinical biomarkers, offers future potential for the identification of novel genetic and non-genetic markers of clinical relevance.