AUTHOR=Yang Siwen , Qu Yunhe , Chen Jiyu , Chen Si , Sun Lin , Zhou Yifa , Fan Yuying 

TITLE=Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.688073

DOI=10.3389/fphar.2021.688073

ISSN=1663-9812

ABSTRACT=<p>Insufficient pancreatic β-cell or insulin-producing β-cell are implicated in all types of diabetes mellitus. Our previous studies showed bee pollen polysaccharide RBPP-P improves insulin resistance in type 2 diabetic mice by inhibiting liver fat deposition. However, its potential of regulating β-cell function and integrity is not fully known. Herein, we observed that β-cell proliferation (<italic>n</italic> = 10), insulin synthesis (<italic>n</italic> = 5, <italic>p =</italic> 0.01684) and insulin incretion (<italic>n</italic> = 5, <italic>p =</italic> 0.02115) were intensely activated in MIN6 cells when treatment with RBPP-P. In alloxan-induced diabetic mice, oral administration of RBPP-P (<italic>n</italic> = 10) effectively decreased the blood glucose (<italic>p =</italic> 0.0326), drink intake (<italic>p</italic> &lt; 0.001) and urine (<italic>p</italic> &lt; 0.001). It directly stimulated phosphorylation of p38 (<italic>p =</italic> 0.00439), ERK (<italic>p =</italic> 0.02951) and AKT (<italic>p =</italic> 0.0072) to maintain the islet function and mass. Thus, our data suggest that RBPP-P is a natural compound to regulate β-cell proliferation and function, indicating it might have therapeutic potential against type 1 diabetes.</p>