AUTHOR=Tafazoli Alireza , Guchelaar Henk-Jan , Miltyk Wojciech , Kretowski Adam J. , Swen Jesse J. 

TITLE=Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.693453

DOI=10.3389/fphar.2021.693453

ISSN=1663-9812

ABSTRACT=Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-Generation Sequencing (NGS) technologies are emerging as a more comprehensive and time and cost-effective approach in PGx. This review presents main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both advantages and challenges of implementing NGS-based tests in PGx. Moreover, limitations of each NGS platform are revealed, and solutions for set up and management of these technologies in clinical practice are addressed.