AUTHOR=Qiao Dan , Zhang Ziwei , Zhang Yali , Chen Qian , Chen Yujun , Tang Yingjue , Sun Xiong , Tang Zhipeng , Dai Yancheng 

TITLE=Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.697360

DOI=10.3389/fphar.2021.697360

ISSN=1663-9812

ABSTRACT=Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly involves the rectum, colonic mucosa, and submucosa. A large number of studies have shown that endoplasmic reticulum stress (ERS)-induced autophagy plays an important role in the pathogenesis of UC. ERS is a homeostasis imbalance caused by misfolded or unfolded proteins aggregated in the endoplasmic reticulum (ER) cavity. And excessive ERS triggers the unfolded protein response (UPR), increase in inositol-requiring enzyme 1, and the overload of Ca2+, which activate the autophagy pathway. Autophagy is a conservative way of cellular self-degradation. Dysregulated autophagy causes inflammation, Disruption of the Intestinal Barrier, and imbalance of   intestinal homeostasis, thus increasing the risk of intestinal diseases. This study reviewed the pathogenesis of ERS, UPR, and autophagy in UC, so as to provide potential new targets and more effective treatment options for UC.