AUTHOR=Wang Wenfei , Wang Yichun , Zou Junbo , Jia Yanzhuo , Wang Yao , Li Jia , Wang Changli , Sun Jing , Guo Dongyan , Wang Fang , Wu Zhenfeng , Yang Ming , Wu Lei , Zhang Xiaofei , Shi Yajun 

TITLE=The Mechanism Action of German Chamomile (Matricaria recutita L.) in the Treatment of Eczema: Based on Dose–Effect Weight Coefficient Network Pharmacology

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.706836

DOI=10.3389/fphar.2021.706836

ISSN=1663-9812

ABSTRACT=To determine the active ingredients in German chamomile volatile oil and the mechanism of action  in the treatment of eczema , this study uesd two parameters  (ingredient content and oil-water partition coefficient) and established a new network pharmacology method based on  dose-effect weight coefficient . Through the new network pharmacology method, we found that German chamomile volatile oil  regulated T cell lymphatic subpopulations to inhibit the Th17 cell differentiation signaling pathway. This resulted in a reduction of interleukin 17(IL-17), thereby inhibiting  activation of the nuclear factor kappa beta （NF-κB）and MAPK pathways,decreasing the secretion of the pro-inflammatory factors (tumor necrosis factor alpha(TNF-α) and Interleukin 6（IL-6),and reducing inflammation. In this study, a new dose-effect relationship synergistic network pharmacology method was established to provide a new method for the screening of effective ingredients and pathways of drugs, and to provide a basis for follow-up studies of German chamomile volatile oil in the treatment of eczema.