AUTHOR=Chen Bangjie , Rao Xianyue , Wang Xinyi , Luo Zhipan , Wang Jianpeng , Sheng Shuyan , Liu Yuchen , Zhang Ning , Jin Shiyu , Chen Haosong , Sun Chenyu , Xu Tao , Du Yingying 

TITLE=cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical Practice

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.719644

DOI=10.3389/fphar.2021.719644

ISSN=1663-9812

ABSTRACT=cGAS-STING signaling pathway is an autoimmune inflammatory pathway discovered in 2013, which can trigger the expression of a series of inflammatory factors represented by type 1 interferon. As an important immune organ, cGAS-STING signaling pathway plays a significant role in liver physiology. Recent studies have found that cGAS-STING signaling pathway is closely related to the progress of liver diseases. For example, activation of cGAS-STING signaling pathway can significantly inhibit HBV replication in vivo. This review summarizes the role of cGAS-STING signaling pathway in several common liver diseases, especially reviews the current application advances of cGAS-STING signaling pathway in the liver disease therapy, and prospects its future research and application combined with frontier fields, suggesting a potential  therapeutic target for liver disease.