AUTHOR=Chen Wen-jian , Yu Xiao , Yuan Xin-Rong , Chen Bang-jie , Cai Na , Zeng Shuo , Sun Yuan-song , Li Hai-wen 

TITLE=The Role of IL-36 in the Pathophysiological Processes of Autoimmune Diseases

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.727956

DOI=10.3389/fphar.2021.727956

ISSN=1663-9812

ABSTRACT=A member of the interleukin (IL) -1 superfamily was IL-36, which contained IL-36α, IL-36β, and IL-36γ, IL-36Ra. The heterotrimer complexes which was consisted of the bounding with IL-36 agonists (IL-36α, β, γ) and heterodimeric receptor complexes gave the signal through intracellular functional domains. And the functional domain could combine the downstream proteins and induce inflammatory responses. IL-36 agonists upregulated mature-associated CD80, CD86, and MHCII and inductively produced several pro-inflammatory factors by the IL-36R-dependent manner in dendritic cells (DCs), which had a strong ability to initiate the helper T (Th) cells differentiation. Up to date, the role of IL-36 in immunity, inflammation and other illnesses is magnificently of great importance. In this summary, we will briefly conclude the biological characteristics and the nearest advances of IL-36 in the development tendency and pathogeny of autoimmune diseases. This information may provide new directions and suggestions for the future research and the treatment of autoimmune diseases.