AUTHOR=Jiang Lin , Li Yunhe , Wang Liye , Guo Jian , Liu Wei , Meng Guixian , Zhang Lei , Li Miao , Cong Lina , Sun Meiyan 

TITLE=Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.767642

DOI=10.3389/fphar.2021.767642

ISSN=1663-9812

ABSTRACT=Lysozymes are naturally occurring enzymes present in a variety of biological organisms, such as bacteria, fungi, and animal bodily secretions and tissues. It is well known that lysozymes and lysozyme-like enzymes can be used as antibacterial agents, as well as inhibit fungi, yeasts, and viruses. Lysozyme is also an important component of the innate immune system in most mammals. In recent years, more evidence has shown the immune-modulatory effects of lysozymes against infection and inflammation. In addition, recent studies revealed the anti-cancer activities of lysozyme in multiple types of tumors, potentially through its immune-modulatory activities. The levels of lysozyme are associated with cancers and other diseases. This review summarized the major features and mechanisms of lysozymes highlighting the prognostic and therapeutic applications and recent advances of lysozymes in cancers, hypertension, and viral diseases.