AUTHOR=Zhao Yao-Zhong , Dai Yong-Zhao , Nie Ke 

TITLE=Research Progress on the Antiemetic Effect of Traditional Chinese Medicine Against Chemotherapy-Induced Nausea and Vomiting: A Review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.790784

DOI=10.3389/fphar.2021.790784

ISSN=1663-9812

ABSTRACT=Chemotherapy-induced nausea and vomiting (CINV), a common side effect in anti-neoplastic treatment, dramatically decreases the quality of life as well as the compliance of cancer patients. Although numerous antiemetic agents have been used for CINV treatment, its adverse reactions as well as its inadequate control toward delayed emesis still limit the clinical usage. Traditional Chinese Medicine (TCM), with more than 3000 years of practical history in Asia, have successfully applied to mitigate chemotherapy-induced side effects. A growing attention is drawn on the antiemetic effect of TCM against CINV due to its promising therapeutic property and relatively higher security recently. In this review, we summarize the classical antiemetic TCM-based treatments and its mechanisms, so as to provide a theoretical basis for further investigations of TCM against CINV in the future.