AUTHOR=Zhang Peng , Wang Lei , Chen Xiuying , Li Xiang , Yuan Qinghai 

TITLE=Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.795012

DOI=10.3389/fphar.2021.795012

ISSN=1663-9812

ABSTRACT=Bi-based nanomaterials, such as Bi2Se3, play an significant role in the field of biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. In this study, polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthesis method at room temperature (25℃). These nanodots exhibit superior CT imaging performance, and can be used as effective photothermal reagents owing to their broad ultraviolet–visible–near infrared absorption. Moreover, under 808 nm irradiation, PEI-Bi2Se3 nanodots exhibit excellent photothermal conversion efficiency of up to 41.3%. Moreover, good biocompatibility and significant tumor ablation capabilities have been confirmed through in vitro and in vivo studies. All the positive results have revealed that the PEI-Bi2Se3 nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancerous tumor.