AUTHOR=Guo Wenyi , Chen Shihong , Li Chengqing , Xu Jianwei , Wang Lei 

TITLE=Application of Disulfiram and its Metabolites in Treatment of Inflammatory Disorders

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.795078

DOI=10.3389/fphar.2021.795078

ISSN=1663-9812

ABSTRACT=Disulfiram has been used clinically for decades as an anti-alcoholic drug. Recently, several studies demonstrate the anti-inflammatory effects of disulfiram, which can alleviate the progression of inflammation in vivo and in vitro. In the current study, we summarize the anti-inflammatory mechanisms of disulfiram, including inhibition of pyroptosis by either covalently modifying gasdermin D or inactivating nod-like receptor protein 3 inflammasome, dual effects of intracellular reactive oxygen species production, and inhibition of angiogenesis. Furthermore, we review the potential application of disulfiram in treatment of inflammatory disorders, such as inflammatory bowel disease, inflammatory injury of kidney and liver, type 2 diabetes mellitus, sepsis, uveitis, and osteoarthritis.