AUTHOR=Li Huajie , Yu Zhenjie , Sun Haoyi , Liu Bo , Wang Xin , Shao Zhe , Wang Meiling , Xie Weilin , Yao Xingang , Yao Qingqiang , Zhi Ying 

TITLE=Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 12 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.821518

DOI=10.3389/fphar.2021.821518

ISSN=1663-9812

ABSTRACT=A novel formal [4+1] annulation between N-(o-chloromethyl)aryl amides and  3-chlorooxindoles through in situ generated aza-ortho-QM with 3-chlorooxindoles is reported for the synthesis of a series of 2,3'-spirobi[indolin]-2'-ones in high yields. Under structured illumination microscopy, compound 3a is found to change the mitochondrial morphology and induce mitophagy pathway, which would then trigger apoptosis in cancer cells.