AUTHOR=Hassan Syed Shams ul , Samanta Saptadip , Dash Raju , Karpiński Tomasz M. , Habibi Emran , Sadiq Abdul , Ahmadi Amirhossein , Bungau Simona 

TITLE=The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1015835

DOI=10.3389/fphar.2022.1015835

ISSN=1663-9812

ABSTRACT=Oxidative stress (OS) disrupts the chemical integrity of macromolecules, and increases the risk of neu-rodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant properties and protects the cells against OS. We have viewed the NCBI database, PubMed, Science Direct (Elsevier), Spring-er-Nature, ResearchGate, and Google Scholar databases to search and collect relevant articles during the preparation of this review. The searching keywords are OS, neurodegenerative diseases, fisetin, etc. High level of ROS in the brain tissue decreases ATP levels, mitochondrial membrane potential and induces lipid peroxidation, chronic inflammation, DNA damage, and apoptosis. The subsequent re-sults are various neuronal diseases. Fisetin is a polyphenolic compound, commonly present in dietary ingredients. The antioxidant properties of this flavonoid diminish oxidative stress, ROS production, neurotoxicity, neuro-inflammation, and neurological disorders. Moreover, it maintains the redox pro-files, mitochondrial functions and inhibits NO production. At the molecular level, fisetin regulates the activity of PI3K/Akt, Nrf2, NF-κB, protein kinase C, and MAPK pathway to prevent OS, inflammatory response, and cytotoxicity. The antioxidant property of fisetin protects the neural cells from inflamma-tion and apoptotic-degeneration. Thus, it can be used in the prevention of neurodegenerative disorders.