AUTHOR=Fang He , Li Hanyang , Zhang Hang , Wang Shu , Xu Shuang , Chang Li , Yang Yongsheng , Cui Ranji 

TITLE=Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1019312

DOI=10.3389/fphar.2022.1019312

ISSN=1663-9812

ABSTRACT=The reprogramming of cellular metabolism is frequently linked to tumorigenesis. Glucose, fatty acids, and amino acids are the substrates that help an organism maintain metabolic equilibrium. The HADH gene codes for the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH), a crucial enzyme in fatty acid oxidation that catalyzes the third phase of fatty acid oxidation in mitochondria. Increasing data suggests that HADH is expressed differently in various types of malignancies and is linked to carcinogenesis and progression. The significance of HADH in malignancies and probable mechanisms of action of HADH in the onset and progression of certain cancers are summarized in this article. The role of HADH as a possible target for the detection and therapy of various malignancies is investigated in this article.