AUTHOR=Xiong Fei , Zhou Qiao , Huang Xiaobo , Cao Peng , Wang Yi 

TITLE=Ferroptosis plays a novel role in nonalcoholic steatohepatitis pathogenesis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1055793

DOI=10.3389/fphar.2022.1055793

ISSN=1663-9812

ABSTRACT=Ferroptosis relies on iron, and ferroptotic cell death is triggered when the balance of the oxidation‒reduction system is disrupted by excessive lipid peroxide accumulation. A close relationship between ferroptosis and nonalcoholic steatohepatitis (NASH) is formed by phospholipid peroxidation substrates, bioactive iron, and reactive oxygen species (ROS) neutralization systems. Further study into ferroptosis during NASH development might reveal NASH pathogenesis and drug targets, as indicated by recent research. Our review explores NASH pathogenesis due to ferroptotic mechanisms. Moreover, it explores mitochondrial dysfunction in ferroptosis. Finally, potential pharmacological therapies directed to ferroptosis in NASH are discussed.