AUTHOR=Li Wenlian , Yang Kejia , Li Bin , Wang Yunxiang , Liu Jing , Chen Dapeng , Diao Yunpeng 

TITLE=Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1060104

DOI=10.3389/fphar.2022.1060104

ISSN=1663-9812

ABSTRACT=Intestinal ischemia reperfusion (II/R) is a clinical emergency that frequently occurs in a variety of clinical conditions. Severe intestinal injury released cytotoxic substances and inflammatory mediators which can activate local inflammatory response and bacteria translocation and trigger multi-organ failure including lung injury which is common complications of II/R injuries and contributes to high mortality rate. Corilagin (Cor) is a natural ellagitannin found in a variety of plants and has been shown many biological and pharmacological properties such as antioxidant, anti-inflammatory, anti-apoptosis. However, no studies have reported the effects and molecular mechanisms of Cor in alleviating II/R-induced intestinal and lung damage. In this study, Cor was found to significantly alleviate II/R-induced pathological damage, inflammatory response, oxidative stress, NLRP3 inflammasome activation, and pyroptosis in intestinal and lung tissues both in vivo and in vitro. Further, Cor also inhibited LPS/Nigericin-induced NLRP3 inflammasome activation and pyroptosis in RAW264.7, MLE-12, and IEC-6 cells, indicates an amelioration of Cor in II/R-induced intestinal and lung injury via inhibiting NLRP3 inflammasome activation and pyroptosis. Thus, Cor might be a potential therapeutic agent for II/R-induced inflammation and tissue injuries.