AUTHOR=Zhu Wenfang , Zhang Yiwen , Wang Yinghong 

TITLE=Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1103309

DOI=10.3389/fphar.2022.1103309

ISSN=1663-9812

ABSTRACT=Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition, which can be caused by a wide range of diseases, such as pneumonia, sepsis, traumas, and the most recent, COVID-19. Even though we have gained an improved understanding of ALI/ARDS pathogenesis and treatment mechanism, there is still no effective treatment for ALI/ARDS, which is partly responsible for the unacceptable mortality rate. In the pathogenesis of ALI, the inflammatory storm is the main pathological feature. More and more evidences show that immune cells and cytokines secreted by immune cells play an irreplaceable role in the pathogenesis of ALI. Therefore, here we mainly reviewed the role of various immune cells in ALI from the perspective of immunotherapy, and elaborated the crosstalk of immune cells and cytokines, aiming to provide novel ideas and targets for the treatment of ALI.